Constraining an Irregular Peptide Secondary Structure through Ring‐Closing Alkyne Metathesis
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چکیده
منابع مشابه
Constraining an Irregular Peptide Secondary Structure through Ring‐Closing Alkyne Metathesis
Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein-protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the stabilization of α-helices, which limits their general applicability. Here we report for the fir...
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Despite the tremendous impact of alkene ring-opening metathesis polymerization (ROMP) on the design and the synthesis of polymers and functional materials, examples for the analogous alkyne ROMP remain scarce. This imbalance can be rationalized by the limited availability of commercially available catalysts and the lack of alkyne metathesis monomers. We present here the synthesis and a systemat...
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This paper presents the evolution of alkyne metathesis since the early discoveries, essentially from the catalyst point of view. It is shown that although well defined carbynes may be useful for this reaction, further work has been made, aimed at the synthesis of new catalysts or catalytic systems, based on molybdenum precursors , associated or not with phenolic cocatalysts. The major objective...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2016
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.201600362